Bortezomib Kabi Caution For Usage

INCOMPATIBILITIES: This medicinal product must not be mixed with other medicinal products except those mentioned in "Method of Administration" under Dosage & Administration.
Instructions for Use and Handling and Disposal: Administration Precautions: BORTEZOMIB is an antineoplastic. Caution should be used during handling and preparation. Proper aseptic technique should be used. Use of gloves and other protective clothing to prevent skin contact is recommended. In clinical trials, local skin irritation was reported in 5% of patients, but extravasation of BORTEZOMIB was not associated with tissue damage.
When administered subcutaneously, alternate sites for each injection (thigh or abdomen). New injections should be given at least one inch from an old site and never into areas where the site is tender, bruised, red, or hard.
There have been fatal cases of inadvertent intrathecal administration of BORTEZOMIB. BORTEZOMIB is for IV and subcutaneous use only. DO NOT ADMINISTER BORTEZOMIB INTRATHECALLY.
Reconstitution/Preparation for Intravenous and Subcutaneous Administration: The contents of each vial should be reconstituted only with normal (0.9%) saline according to the following instructions based on route of administration: (See Table 30.)

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The reconstituted product should be a clear and colorless solution. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. If any discoloration or particulate matter is observed, the reconstituted product should not be used.
Procedure for Proper Disposal: Any unused product or waste material should be disposed of in accordance with local requirements.